Nicardipine Versus Labetalol During Intubation

Seoul National University Bundang Hospital70 enrolled

Overview

The aim of this study was to compare the efficacy of nicardipine and labetalol in attenuation of cardiovascular responses to endotracheal intubation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Patients Who Are Intubated for General Anesthesia Endotracheal Intubation

Interventions

labetalolDRUG

0.4 mg/kg labetalol intravenously 4 min before intubation

nicardipineDRUG

20 ㎍/kg nicardipine intravenously 4 min before intubation

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients scheduled for general anesthesia with endotracheal intubation Exclusion Criteria: * Patients with heart failure or coronary artery disease 2-3 degree atrio-ventricular block or severe bradycardia (\< 45 beats/min) asthma, bronchial spasm or chronic obstructive pulmonary disease patients with anticipated difficult intubation (Mallampati class III, IV) severe hepatic or renal dysfunction allergy or contraindication to study medication

Locations (1)

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

RECRUITING

Outcomes

Primary Outcomes

hemodynamic variables (systolic blood pressure, diastolic blood pressure and mean blood pressure, heart rate)

Time frame: preinduction- 10 min after intubation

Central Contacts

Jung-Hee Ryu, Ph.D

CONTACT

82-31-787-7497 jinaryu@lycos.co.kr

Data from ClinicalTrials.gov

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