Pilot Study of Auto-immune Abnormalities Associated With Down Syndrome

Institut Jerome Lejeune72 enrolled

Overview

The purpose of the study is to identify biological data linked to auto immune abnormalities associated with Down Syndrome.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Down Syndrome With and Without Auto Immune Abnormalities

Eligibility

Sex: ALLMin age: 8 YearsMax age: 36 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Free and complete trisomy 21 * aged between 8 and 36 years * biological or clinical signs of auto-immune disorder (group 1) * no sign of auto-immune disorder (group 2) Exclusion Criteria: * any antimitotic or immune depressing treatment during the last 6 months * Current infectious disease * Corticosteroid therapy in the last 3 weeks * pregnancy

Locations (2)

Institut Jerome Lejeune

Paris, France

Laboratoire d'Immunologie Biologique (Unité INSERM U580)

Paris, France

Outcomes

Primary Outcomes

Auto-antibodies dosage

Time frame: at enrolment

specific lymphocytes populations count

Time frame: at enrolment

Data from ClinicalTrials.gov

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