The objective of this study is to evaluate the influence of different propofol formulations(plain or with lidocaine)on anesthetic induction. Propofol plain or with lidocaine is administered using a closed-loop algorithm in order to reach a Bispectral Index target of 50.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
212
Propofol with saline is administered using a closed-loop algorithm which permits to reach a Bispectral Index target of 50. The blinded syringe contains 45 ml of propofol and 5 ml of saline.
Propofol with lidocaine 1¨% is administered using a closed-loop algorithm which permits to reach a Bispectral Index target of 50. The blinded syringe contains 45 ml of propofol and 5 ml of lidocaine.
Propofol with saline is administered using a closed-loop algorithm which permits to reach a Bispectral Index target of 50. The blinded syringe contains 45 ml of propofol and 5 ml of saline.
Clinique Saint Augustin
Bordeaux, France
Laboratoire de Pharmacologie Toxicologie, hôpital Raymond Poincaré
Garches, France
Hôpital Foch
Suresnes, France
necessary dose of propofol to obtain the induction of anesthesia (defined by a bispectral index of 50)
Time frame: end of anesthetic induction
calculated concentrations of propofol at the end of the anesthetic induction
Time frame: end of the anesthetic induction
measured plasma propofol concentrations at the end of anesthetic induction (in 20% of patients)
Time frame: 3 months after the end of patient's recruitment
pain at injection
Time frame: during the PACU (post-anaesthesia care unit) stay
heart rate and arterial pressure modifications induced by anesthetic induction
Time frame: end of anesthetic induction
patients satisfaction
Time frame: during the PACU stay
necessary dose of propofol to obtain loss of consciousness
Time frame: end of anesthetic induction
calculated concentrations of propofol at loss of consciousness
Time frame: end of anesthetic induction
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Propofol with lidocaine 1¨% is administered using a closed-loop algorithm which permits to reach a Bispectral Index target of 50. The blinded syringe contains 45 ml of propofol and 5 ml of lidocaine.
Propofol with saline is administered using a closed-loop algorithm which permits to reach a Bispectral Index target of 50. The blinded syringe contains 45 ml of propofol and 5 ml of saline.
Propofol with lidocaine 1¨% is administered using a closed-loop algorithm which permits to reach a Bispectral Index target of 50. The blinded syringe contains 45 ml of propofol and 5 ml of lidocaine.