Safety, Pharmacokinetics and Pharmacodynamics of DSP-8658 in Patients With Type 2 Diabetes Mellitus and Healthy Adults

Inclusion Criteria: Diabetic subjects * Age ≥ 18 and ≤ 65 years * Body Mass Index ≤45 * Drug naive type 2 diabetes or type 2 diabetes previously treated with an oral antidiabetic drug Inclusion Criteria: Healthy subjects * Age ≥ 18 and ≤ 65 years * Body Mass Index ≥ 18 and ≤ 29 * Good health as determined by medical history, ECG, clinical chemistry, hematology, urinalysis, virology, and a physical examination. Exclusion Criteria: Diabetic subjects * Have a current or expected requirement for any antidiabetic or lipid-lowering drug Exclusion Criteria: Healthy subjects * Have, or have had a history of clinically significant neurological, urological, gastrointestinal, renal, hepatic, cardiovascular, psychological, pulmonary, metabolic, endocrine, hematological, or other major disorders including cancer