Evaluation of Image Quality Over Time After Injection of the ﬂuorescein Sodium for Confocal Laser Endomicroscopy

Shandong University20 enrolled

Overview

Confocal laser endomicroscopy (CLE) is a newly developed endoscopic technique. The most commonly used fluorescent substance is Fluorescein sodium.The plasma half-life of ﬂuorescein is 11 minutes. A recent test estimated that ﬂuorescein-based CLSM(confocal laser scanning microscopy) of the upper-GI tract of pigs delivers the best contrast and image quality within the ﬁrst 8 minutes after injection of ﬂuorescein .However, despite its increasing use in clinical examination,there are no data on contrast dynamics and image quality over time after injection of the ﬂuorescein sodium in the inspection of gastrointestinal tract of human being.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Change of Image Quality of CLE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * These subjects will include male or female aged between 18 and 60 years with indications for upper-endoscopy ,but without serious gastritis and other serious stomach lesions Exclusion Criteria: * Complications such as gastric and/or duodenal peptic ulcer, stenosis * Esophageal, gastric or duodenal cancer or other malignancy * History of stomach surgery * A history of bronchial asthma, or known allergy to fluorescein. * Pregnant or breast-feeding (for females) * Below 18 or above 60 years of age * Severe comorbidities ( e.g. such as renal failure, congestive cardiac failure, liver cirrhosis).

Evaluation of Image Quality Over Time After Injection of the ﬂuorescein Sodium for Confocal Laser Endomicroscopy

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes