Oral Peptones Load in Normocalcemic and Hypercalcemic Primary Hyperparathyroidism and Healthy Subjects

University of Eastern Piedmont60 enrolled

Overview

The purpose of this study is to assess if subjects with hyperparathyroidism with normal serum calcium levels have different responses in the calcium regulating hormonal handling compared to a) patients with primary hyperparathyroidism and high serum calcium levels; b) healthy subjects. The differences will be evaluated with oral peptones load and subsequent blood samples collected every 15 minutes for two hours. Ionized calcium, phosphate, gastrin and PTH levels will be evaluated.

Study Type

INTERVENTIONAL

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Hyperparathyroidism Hypercalcemia

Interventions

Oral peptones loadOTHER

Enrolled subjects will receive 10 g Liebig meat extract diluted in 250ml of 0.9% saline

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. normocalcemic hyperparathyroidism * presence of high serum levels of intact PTH * serum ionized calcium levels in the high normality range 2. hypercalcemic hyperparathyroidism * presence of high serum levels of intact PTH * high serum ionized calcium levels Exclusion Criteria: 1. potential causes of secondary hyperparathyroidism like renal insufficiency, liver disease, malabsorption, hypercalciuria, Paget's disease, thiazide diuretic or lithium use. 2. bone disease of any origin

Locations (1)

L. Sacco Hospital (Vialba)

Milan, MI, Italy

Outcomes

Primary Outcomes

PTH levels variations

Time frame: 2 hours

Ionized serum calcium variations

Time frame: 2 hours

Serum phosphate variations

Time frame: 2 hours

Serum gastrin variations

Time frame: 2 hours

Data from ClinicalTrials.gov

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