Impact of Air Pollution on the Autonomic Nervous System Activity and the Presence of Sleep Apnea in Older Subjects

Centre Hospitalier Universitaire de Saint Etienne60 enrolled

Overview

Impact of air pollution on the autonomic nervous system activity and presence of sleep apnea in older subjects.

The relation between the air pollution and morbidity, cardiovascular mortality was increasing interest. Analyses show an increase of respiratory difficulty, but also cardiac deaths in the daytime when the atmospheric pollution was increased. It was demonstrated that health effects of ambient air pollution in subjects presenting cardiac or lung difficulty were important. Mechanisms show a possible relation to autonomic nervous system (ANS) deactivation and mortality. Particularly, the ageing and ANS reach would be more predictive of cardiovascular events. Thus, we suggest estimating in 60 healthy volunteers from 60 to 80 years old, the impact of the air pollution on the autonomic nervous system activity and sleep apnea consequences.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Healthy

Interventions

Air pollution study on healthy volunteers.OTHER

The subjects are examined three times: * First the volunteers get used to equipments. * Second and third the volunteers sleep in a pollution or purified air.

Eligibility

Sex: ALLMin age: 60 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * reside in Lyon and Saint-Etienne cities * security social affiliated or beneficiary * information note signed Exclusion Criteria: * heart rate disorders * pacemaker * tabacco addiction or second-hand smoke * morbid obesity (BMI \> 30) * insulin-dependent diabetes * chronic disease on treatment * antiarrythmic treatments

Locations (2)

Hospices Civiles de Lyon

Lyon, France

CHU Saint-Etienne

Saint-Etienne, France

Outcomes

Primary Outcomes

Frequency analysis of heart rate variability

Time frame: inclusion, 1 test night and 2 experimental nights

Secondary Outcomes

Analysis of sleep, diurnal somnolence, sleep latency and PRS impact on the life quality.

Time frame: 1 test night and 2 experimental nights

Hour index quantification of night respiratory events.

Time frame: 1 test night and 2 experimental nights

Hour index quantification of autonomic awakening during the sleep.

Time frame: 1 test night and 2 experimental nights

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.