Safety, Pharmacokinetic and -Dynamic Study of PR-15, an Inhibitor of Platelet Adhesion

Inclusion Criteria: * Healthy, male Caucasians between 18 and 45 years of age. * Normotensive subjects (systolic BP \< 140 mmHg and diastolic BP \<90 mmHg; * Body weight of 70 to 90 kg (BMI 20 - 25. * Negative results in HIV antibody, HBs antigen (HBsAg) and HCV tests; * Signed Informed Consent Form. * Normal coagulation function (aPTT between 24 and 35 seconds, PT between 70 and 130%, INR between 0.85 and 1.15. Exclusion Criteria: * Subjects who are taking or have taken any prescription medication within the last 14 days or any non-prescription medication, especially, anti-platelet drugs, within the last seven days prior to the administration of trial medication on Day 1. * Intake of any investigational drug within three months prior to the administration of study medication on Day 1. * Concomitant use of any other medication including over-the-counter preparations. * History of hypersensitivity, contraindication or serious adverse reaction to inhibitors of platelet aggregation or hypersensitivity to related drugs (cross-allergy) or to any of the excipients in the study drug. * A history or clinical evidence of any cardiac, cardio- or cerebrovascular, hepatic, renal, pulmonary, endocrine, neurological, infectious, gastrointestinal, haematological, oncological or psychiatric disease or emotional problems or any other clinically relevant condition, physical finding, ECG- or laboratory test abnormality, which - in the opinion of the investigator - would pose a significant risk for the subject, invalidate the Informed Consent or limit the ability of the subject to comply with study requirements or interfere otherwise with the conduct of the study. * Any laboratory value outside the normal laboratory reference range at Screening and before randomization, unless approved by the investigator. * Subjects known to have experienced elevated liver enzyme values will also be excluded. * History of alcohol and/or drug abuse (verified by drug screening). * Blood loss of 450 ml or more during the last three months before Screening. * Subjects who smoke more than 5 cigarettes per day and/or are unable to abstain from smoking during the entire in-house period. * Subjects who were previously enrolled in this trial or who have received PR-15 in a previous trial. * Subjects who have participated in other clinical trials in the last 3 months.