The purpose of this study is to evaluate the impact of different ligands of GPR 119 (a G protein-coupled receptor in the intestine) on the secretion of the incretin hormones, GLP-1 and GIP.
We have found a new ligand for the GPR 119 receptor. This study evaluate the impact of this ligand on the incretion hormone responses, beta cell function and gall bladder function in healthy young men.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
8
Emulgation, 50 ml. containing 2g 2OG
Emulgation, 50 ml. containing 1.54g of oleic acid
Fifty milliliters of glycerol (Sigma-Aldrich; batch 32296AK, purity 99%) plus 5 ml 96% ethanol
Department of Clinical Physiology, Glostrup Hospital
Glostrup Municipality, Denmark
The effect of this newly discovered GPR 119 agonist on gut hormone responses, in particular GLP-1 in response of the different meals administered to the subjects
Time frame: 1 year
Glucose homeostasis, gall bladder contraction in response of the different meals administered to the subjects
Time frame: 1 year
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