Dose Escalation Radiotherapy With Modulation of Intensity and Integrated Boost (SIB-IMRT) in the Treatment of Glioblastomas in Adults

Inclusion Criteria: * Histopathologically proven diagnosis of glioblastoma (WHO grade IV astrocytoma) * Diagnosis must be obtained by a stereotactic or surgical biopsy * Age between 18 and 70 * Total or partial surgical resection deemed as not possible by a neurosurgeon * OMS performance status 0 or 1 * Adequate blood function : absolute neutrophil count \> 1.5 x 109/L, platelets count \> 100 x 109/L platelets; * Adequate liver function: bilirubin \< 1.5 ULN (upper limit of normal), ALT and AST \< 3 ULN, * Adequate renal function: creatinine \< 1.5 ULN * Patient must have been informed and must have signed the specific informed consent form. Exclusion Criteria: * other malignancy histology * resection of the brain tumor complete on MRI exploration * patient unable to give informed consent * patient presenting counter-indication to MRI exploration * patient must not have received neither radiotherapy nor chemotherapy for that affection * concomitant malignancy * patient already enrolled in another biomedical study with an experimental molecule * pregnant, nursing woman, or without contraception * private individuals of freedom or under tutelage (including legal guardianship) * psychiatric, behavioural disorders or geographical situation precluding the administration or follow-up of the protocol (including claustrophobia)