Efficacy and Safety of Utapine vs. Seroquel in Patients With Bipolar Mania

Inclusion Criteria: 1. Male or female age 18-65 years with diagnosis of bipolar I disorder who will be included by DSM-IV criteria made at least one manic or mixepisode record before study entry. 2. Having a minimum score of 20 on the Young Mania Rating Scale (YMRS), plus a score of at least 4 on two of the core YMRS items of Irritability,Speech, Content, and Disruptive/Aggressive Behavior. 3. At least 4 will be on the Severity of Illness item of the Clinical Global ImpressionsNBipolar(CGINBP)assessment tool. 4. Patient with good compliance to study medicine and adherence to study protocol. Exclusion Criteria: 1. Had received treatment with clozapine within 28 days of the start of the trial. 2. Had been hospitalised for 3 weeks or longer for the index manic episode. 3. DSM-IV criteria for rapid cycling or a current mixed episode. 4. Intolerance or lack of response to quetiapine or clozapine before this trial be diagnosed by investigator. 5. Neurodegenerative disease eg:Parkinson desease、Huntington disease、Pick's disease. 6. Medicine or drugs which can change mental condition be judged by investigator. 7. EKG abnormality 8. Drug or alcohol abuser