Micropulse 577 nm Laser Photocoagulation Versus Conventional 532 nm Laser Photocoagulation for Diabetic Macular Oedema

Inclusion Criteria: * Diabetes mellitus (type 1 or 2) * Diabetic macular edema in study eye associated to diabetic retinopathy * Diffuse macular edema defined as macular thickening determined by biomicroscopy, OCT and/or fluorescein angiography. * Best corrected visual acuity between 34 (20/200) and 68 letters (20/50). * Macular thickness greater than 300 mcm on OCT. Exclusion Criteria: * Significant renal disease, defined as a history of chronic renal failure requiring dialysis or kidney transplant. * A condition that, in the opinion of the investigator, would preclude participation in the study (e.g., unstable medical status including blood pressure, cardiovascular disease, and glycemic control). * Blood pressure \> 180/110 (systolic above 180 OR diastolic above 110). * Subject is expecting to move out of the area of the clinical center to an area not covered by another clinical center during the next 6 months. The following exclusions apply to the study eye only (i.e., they may be present for the nonstudy eye): * Macular edema is considered to be due to a cause other than diabetic macular edema. * Presence of vitreomacular traction. * Concurrent proliferative diabetic retinopathy. * An ocular condition is present such that, in the opinion of the investigator, visual acuity loss would not improve from resolution of macular edema (e.g., foveal atrophy, pigment abnormalities, dense subfoveal hard exudates, significant macular ischemia, nonretinal condition). * An ocular condition is present (other than diabetes) that, in the opinion of the investigator, might affect macular edema or alter visual acuity during the course of the study (e.g., vein occlusion, uveitis epiretinal membrane, or other ocular inflammatory disease, neovascular glaucoma, etc.). * Substantial cataract that, in the opinion of the investigator, is likely to be decreasing visual acuity by 3 lines or more (i.e., cataract would be reducing acuity to 20/40 or worse if eye was otherwise normal). * History of treatment for DME at any time in the past 4 months (such as focal/grid macular photocoagulation, intravitreal or peribulbar corticosteroids, anti-VEGF drugs, or any other treatment). * History of panretinal (scatter) photocoagulation (PRP) prior to enrollment or anticipated to be performed within next 6 months. * History of major ocular surgery (including vitrectomy, cataract extraction, scleral buckle, any intraocular surgery, etc.) within prior 12 months or anticipated within the next 6 months. * History of YAG capsulotomy performed within 2 months prior to enrollment.