Pharmacokinetics of Tranexamic Acid (TXA) in Children Undergoing Repair of Congenital Heart Defects Utilizing Cardiopulmonary Bypass

Boston Children's Hospital55 enrolled

Overview

The purpose of this study is to measure blood levels of TXA in children having cardiac surgery which requires cardiopulmonary bypass. TXA is used to reduce bleeding during surgery. This study will help determine if the current dosing of TXA results in therapeutic blood levels.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Congenital Heart Disease

Eligibility

Sex: ALLMax age: 21 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * congenital heart disease requiring surgical repair with cardiopulmonary bypass Exclusion Criteria: * children weighing over 20 kg * family does not want to participate in the study

Locations (1)

Children's Hospital Boston

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Determine TXA blood levels in children having cardiac surgery with cardiopulmonary bypass. The current dosing recommendations will be utilized.

Time frame: multiple times thoughout surgery

Data from ClinicalTrials.gov

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