Phlebotomy and Lifestyle and Diet Advices vs Lifestyle and Diet Advices Only in Patients With Dysmetabolic Liversiderosis

Inclusion Criteria: * Age over 18 * Signed written informed consent * Ferritin ≥ 450 µg/L and ≤ 1500 µg/L * Hepatic iron overload proved by MRI or histological biochemical measurement (Iron hepatic concentration ≥ 50 μmol/g) * At least one of the following criteria : * Body mass index \> 25 kg/m² * Systolic blood pressure ≥ 140mmHg or diastolic blood pressure ≥ 90 mmHg or antihypertensive treatment * Abdominal obesity (waist measurement ≥ 94 cm for men and ≥ 80 cm for women) * Fasting triglyceridemia ≥ 1.7 mmol/L or triglyceride-lowering treatment * Fasting HDL cholesterol \< 1.03 mmol/L for men and \< 1.29 mmol/L for women or HDL cholesterol-elevating treatment * Fasting blood glycemia ≥ 5.6 mmol/L Exclusion Criteria: * Subjects deprived of their liberty by judicial or administrative decision * Pregnant women * Other causes of increased serum ferritin levels: * Inflammatory syndrome (CRP \>10 mg/L) or inflammatory, immune or malignant diseases * Hyper-hemolysis * Alcohol consumption more than 210 g for men and 140 g for women per week within the year before inclusion * Haemochromatosis established by the C282Y homozygous genotype * Chronic hepatic cytolysis due to : viral infection (HBV, HCV), alcohol, hyperthyroid disease, celiac disease, drug or immune hepatitis * Increased serum ferritin levels - cataract syndrome (familial cataract or personal history of cataract before 50 years of age) * Low ceruloplasmin level * Porphyria (cutaneous signs) * Contraindication of phlebotomy * Haemoglobin \<13 g/dL for men and \<12g/dL for women (threshold established by the French Blood Agency) * Congestive heart failure or coronary heart disease * Hepatic failure (TP\<60%), renal failure (GFR \<50mL/min) or respiratory insufficiency (chronic dyspnea) * Poor venous system * Fasting blood glycemia \> 7 mmol/L or type 1 or type 2 diabetes, treated or not * Use of drugs known to have anti-steatotic effects : metformin, thiazolidinedione