Investigation of Platelet Function and Aspirin Resistance in Chronic Dialysis Patient

National Taiwan University Hospital300 enrolled

Overview

The purpose of this study is to determine whether aspirin resistance has impact on cardiovascular event in dialysis patient.

Dialysis patient inevitably suffered from uremic bleeding although improvement of dialysis care in the past decades. Physicians used to check bleeding time as a surrogate marker for uremic bleeding. However, bleeding time isn't accurate and as well known, is poorly correlated with clinical bleeding such as surgical bleeding. Platelet function assay (PFA) is a newly developed method to measure platelet aggregation in vitro and is validated in many sorts of platelet disorders. Recently, PFA was also used to evaluate aspirin responsiveness in patients who had taken aspirin. Our study is aim to investigate uremic thrombocytopathy via PFA of dialysis patient in Taiwan. Furthermore, we will study aspirin resistance in dialysis patient.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

End Stage Renal Disease

Eligibility

Sex: ALLMin age: 20 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * dialysis \>3 months * Hb\>10 g/dl \& Plt \> 10000 Exclusion Criteria: * using medication which interfere PFA except aspirin * terminal disease such as malignancy * active vasculitis

Locations (1)

National Taiwan University Hospital

Taipei, Taiwan, Taiwan

Outcomes

Primary Outcomes

cardiovascular event, bleeding event,and thrombosis

Time frame: 1 year

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.