A Study of the Rules for Insulin Dosing in Patients Using Multiple Daily Injections

Inclusion Criteria: * Age: \>17 years * Type 1 diabetes * Diabetes duration \> 3 months * On treatment with multiple daily injections either one or more basal insulin injections each day for 6 weeks * HbA1c \<9.0% * Stable HbA1c in the proceeding 3 months (i.e., change \<1%) * Demonstrated adherence to visits and instructions * Attend a class in meal carbohydrate content estimation or have demonstrated knowledge of carbohydrate counting Exclusion Criteria: * Major stress event during or for 6 weeks before the evaluation * Taking a medication that can alter insulin sensitivity * Within one week of menses * Unstable eating or activity pattern * Pregnancy * Weight gain of \> 1.5 kg during the preceding 3 months * Serum creatinine of \>1.5 mg/dl * Active liver disease * Evidence of autonomic neuropathy, especially gastroparesis * Any antidiabetic medication other than insulin * Treatment with continuous subcutaneous insulin infusion