Perifosine With Temsirolimus for Recurrent Pediatric Solid Tumors

Inclusion Criteria: * Any solid tumor that has failed standard therapy * Patient must have evidence of tumor by CT, MRI, MIBG scan, serum markers, or tissue sampling. * Age ≤ 21 years (age ≤ 35 years for biopsy proven medulloblastoma or neuroblastoma) * Karnofsky/Lansky performance status ≥ 50% (Karnofsky score for age\> 16 years and Lansky score for age ≤ 16 years) * ANC≥ 1000 at least 24 hours off GCSF * Platelets ≥ 100K at least one week off platelet transfusions * Hg≥ 8g/dL at least one week off PRBC transfusion * AST ≤ 2 x the upper limit of normal * ALT ≤ 2 x the upper limit of normal * Total bilirubin ≤ 2.0 mg/dl * Patients must have cholesterol level \< 350 mg/dl and triglycerides level \< 400 mg/dl because temsirolimus can induce hyperlipidemia. * Serum creatinine ≤ 1.5 x the upper limit of normal for age, or calculated creatinine clearance or nuclear GFR ≥ 70 ml/min/1.73 m2. * ≥ 3 weeks since last non-nitrosourea chemotherapy * ≥ 6 weeks since last nitrosoureas * ≥ 4 weeks since last RT * Patients must agree to practice adequate contraception. Females of childbearing potential must have a negative serum B-HCG pregnancy test documented within 14 days prior to registration. Females must not be breast feeding. * Patients must be able to swallow tablets whole * Patients that participated in the phase I single agent perifosine study for recurrent pediatric solid tumors and did not experience a DLT are eligible to participate in this study and can start ≥ 2 weeks since last dose of perifosine * Patients that have been previously treated with an mTOR inhibitor can still enroll in this trial as long as they did not experience a DLT in the single agent mTOR inhibitor trial Exclusion Criteria: * Pregnancy * Patients must not have an uncontrolled active infection. * HIV-Positive patients receiving combination anti-retroviral therapy are excluded from the study due to possible retro-viral drug interactions. HIV testing not required. * Patients must not be taking EIAEDs. If patients were previously on EIAEDs that have been discontinued, patients must have been off the agent for at least 2 weeks prior to registration. * History of or known pulmonary hypertension or history of or known pneumonitis.