Effects of CHONDRON (Autologous Chondrocytes) With Ankle Cartilage Defect

Inclusion Criteria: 1. adult men and women over 15 and less than 65 years of age 2. applied to patients with arthroscopically or grossly confirmed, partial cartilage defect at the ankle joint 3. patients with ankle-tibia malalignment of the ankle joint, unstable ankle ligaments, bone defects at the cartilage defect area or patients who received correction in advance. 4. patients which surrounding cartilage are normal 5. patients who agreed to clinical trial participation voluntarily or by the will of the person in parental authority, and signed the written consent form Exclusion Criteria: 1. patients hypersensitive to bovine protein 2. patients hypersensitive to gentamicin antibiotics 3. patients with inflammatory arthritis such as rheumatoid arthritis, gout arthritis 4. patients with arthritis related to autoimmune disease 5. pregnant, breast-feeding patients or those who have a possibility of pregnancy 6. patients with accompanying diseases other than articular cartilage defects, including tumors 7. patients who have a history of receiving radiotherapy, chemotherapy in the last 2 years 8. patients with diabetes (however, patients whose blood sugar test results are normal and do not have any complication of diabetes, when a written opinion that CHONDRON administration is possible is appended by a doctor are excluded) 9. patients who are administering antibiotics and antimicrobial agents due to infection 10. patients who receive steroid hormone therapy 11. Patients with psychiatric disorder and those who are considered to be inappropriate for this trial by the judgment of the clinical trial manager