Cardio-cerebrovascular Disease and Aspirin Ulcer Relapse Evaluation

Inclusion Criteria: * patients with ischemic heart failure or vascular disease of brain * patients taking low-dose aspirin to prevent relapse of vascular diseases * patients who experienced gastric and/or duodenal ulcers before the study by the endoscopy * patients without active gastric and duodenal ulcers * more than 20 years old * outpatients * patients written an informed consent Exclusion Criteria: * patients with ischemic heart failure, which are acute phase, unstable condition or under 6 months after stent-instillation * patients with brain vascular disease , which are acute phase, unstable condition or under 3 months after the first attack * patients who are uncontrolled and complicated disease, for example thrombocytopenia, and unsuitable for this study as judged by investigator * patients who are treated with steroid hormones * patients who are women of, pregnant and lactating and childbearing * patients who are alcoholism * patients who show the hypersensitivity for test drugs * patients who are enrolled in another clinical study * patients who are judged as unsuitable by investigator