Using a 2x2 complete factorial design, approximately 140 obese men and women who may or may not have type 2 diabetes will be randomized to one of two conditions (70 in each condition): (a) a high fiber diet, or (b) a low-carbohydrate diet. Participants will be instructed to follow their assigned diets for 1 year. Outcome measures of interest will include participants' BMI, waist circumference, blood lipids (total, HDL, and LDL cholesterol, and triglycerides), C-reactive protein, and gastrointestinal peptides. Participants will be recruited from the Loma Linda and San Bernardino city area in southern California.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
173
High fiber diet involves at least 40 grams of dietary fiber or more per day for women and at least 50 grams of dietary fiber per day for men. Low-carbohydrate diet involves less than 120 grams of carbohydrate per day for both men and women.
Loma Linda U Medical Center Diabetes Treatment Center
Loma Linda, California, United States
Weight
Time frame: 1 year
Lipid profiles
Time frame: 1 year
Gastrointestinal hormones
Time frame: 1 year
Waist circumference
Time frame: 1 year
C-reactive protein
Time frame: 1 year
Blood glucose
Time frame: 1 year
Serum insulin
Time frame: 1 year
Hemoglobin A1c
Time frame: 1 year
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