Impact of Nebivolol on Central Aortic Pressure

N/AWithdrawnNCT01051947

Creighton University

Overview

A randomized, cross-over, single-blind study to compare the effects of nebivolol and metoprolol on central aortic pressure and peripheral brachial pressure in patients with stable cardiovascular disease.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Conditions

Central Aortic Pressure

Interventions

NebivololDRUG

10 mg by mouth daily for 2 weeks 20 mg by mouth daily for 2 weeks 40 mg by mouth daily for 2 weeks

MetoprololDRUG

dosage prescribed prior to starting on study

Eligibility

Sex: ALLMin age: 45 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects with history of hypertension * Subjects who have received metoprolol for a minimum of 3 months Exclusion Criteria: * Patients who have had an acute myocardial infarction, coronary revascularization or who have been hospitalized for heart failure or cardiac arrhythmia in the past 6 months

Locations (1)

The Cardiac Center at Creighton University

Omaha, Nebraska, United States

Outcomes

Primary Outcomes

Stable blood pressure

Subjects will be randomized to nebivolol or metoprolol. Their medication will be titrated so that their blood pressure is within 10% of their initial reading.

Time frame: 6 months

Data from ClinicalTrials.gov

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