The Efficacy of Transversus Abdominis Plane Block After Groin Hernia Repair

Glostrup University Hospital, Copenhagen90 enrolled

Overview

The purpose of this study is to determine whether Transversus abdominis plane block is superior to placebo or superior to local infiltration in analgesic efficacy after groin hernia repair.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Hernia

Interventions

Transversus abdominis plane blockPROCEDURE

UL-guided TAP block with 25 ml of ropivacaine 0,75% unilateral, single dose, ilioinguinal block with 10 ml of saline and local infiltration with 40 ml of saline

SalinePROCEDURE

UL-guided Tap block with 25 ml of saline single dose Ilioinguinal block with 10 ml of saline and local infiltration with saline 40 ml single dose

Local infiltrationPROCEDURE

Ilioinguinal block with 10 ml of ropivacaine 0,375% single dose, local infiltration with 40 ml of ropivacaine 0,375% single dose, UL-guided Tap block with 25 ml of saline single dose

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18-75 years old * groin hernia repair * written consent * ASA 1-3 * BMI 18-35 Exclusion Criteria: * unable to communicate in Danish * relevant drug allergy * pain medication in the last 24 hours * pregnancy * alcohol or/and drug abuse * daily opioid intake * infection at injection site

Locations (1)

Department of Anaesthesiology, Glostrup university hospital

Glostrup Municipality, Denmark

Outcomes

Primary Outcomes

Pain scores by coughing between TAP block group and placebo group

Area under the curve (AUC)-pain during cough based on measurements at 0,2,4,6,8,19,24 hours postoperative

Time frame: 0,2,4,6,8,19 and 24 hours postoperative

Secondary Outcomes

Pain scores by coughing between placebo and local infiltration and between TAP block and local infiltration.

Area under the curve (AUC)-pain during cough based on measurements 0,2,4,6,8,19,24 hours postoperative.

Time frame: 0,2,4,6,8,19 and 24 hours postoperative

Total opioid consumption

Total morphine consumption 0-2 hours postoperative. Total ketobemidone consumption 2-24 hours postoperative.

Time frame: 0-24 hours postoperative

Postoperative nausea and vomiting

Levels of nausea (0-3)at 0,2,4,6,8,19,24 hours postoperative Number of vomits 0-2, 2-4, 4-6, 6-8, 8-19 og 19-24 hours postoperative.

Time frame: 0,2,4,6,8,19,24 hours postoperative

Sedation

Levels of sedation (0-3)at 0,2,4,6,8,19,24 hours postoperative.

Time frame: 0,2,4,6,8,19,24 hours postoperative

Pain scores at rest between TAP block versus placebo and TAP block versus infiltration and infiltration versus placebo

Area under the curve (AUC)-pain at rest based on measurements at 0,2,4,6,8,19,24 hours postoperative

Time frame: 0,2,4,6,8,19,24 hours postoperative

Data from ClinicalTrials.gov

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