Curcumin for Type 2 Diabetic Patients

Srinakharinwirot University200 enrolled

Overview

There are evidence that there is an association between insulin resistance and prolonged hyperinsulinemia or hyperglycemia in Type 2 diabetic patients. This will trigger oxidative stress system via reactive oxygen species (ROS) and lead to a high level of Nitric oxide. This can contribute to a significant change in blood vessel and could end up with the complications from cardiovascular disease and increased mortality rate of type 2 diabetic patients. The purpose of the present study was to examine the effectiveness of the curcumin in type 2 diabetic patients on the reduction of atherosclerosis events by examining pulse-wave velocity (PWV) and plasma high-sensitivity C-reactive protein (CRP) test and on blood sugar lowering, glycosylated hemoglobin (HBA1c), lipid profile, and insulin resistance.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

200

Conditions

Type 2 Diabetes Mellitus Cardiovascular Abnormalities

Interventions

Eligibility

Sex: ALLMin age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diabetic patients aged 35 years or older and did not use insulin during the first 5 years of treatment after being diagnosed (with or without symptoms listed in the following inclusion criteria) * Patient with hyperlipidemia (Cholesterol ≥ 200 mg/dl, TG ≥ 150 mg/dl, LDL ≥ 100 mg/dl and HDL ≥ 35 mg/dl) * Patient with hypertension (Blood pressure ≥ 130/85 mmHg or take hypertensive drugs) * Obesity (BMI ≥ 25) Exclusion Criteria: * Current diagnosis of secondary peripheral arterial disease (PAD) (except listed in the inclusion criteria item 1-4) * Current diagnosis of cardiovascular disease, i.e., coronary arterial disease and cerebrovascular disease * Current diagnosis of end stage renal function with serum creatinine \> 2.0 mg/dl or on renal dialysis * Current diagnosis of cirrhosis with ALT ≥ 3 times of normal range

Outcomes

Primary Outcomes

to determine the effectiveness of curcumin on reduction of atherosclerotic events and risks in Type 2 diabetic patients

Time frame: 12 months

Secondary Outcomes

To examine the effectiveness of curcumin on the reduction of blood sugar, glycosylated hemoglobin (HBA1c), lipid profile, and insulin resistance