The aim of the prospective observational GDC-Study in patients with newly diagnosed diabetes mellitus aged 18-69 years at inclusion into the study is to characterize in detail the clinical, metabolical and immunological phenotype and monitor the progression of the disease and to compare the phenotype to glucose tolerant humans of similar age, body mass and sex distribution.
In detail, the following questions will be answered: 1. Are there different phenotypes with respect to insulin secretion, insulin sensitivity, micro- and macrovascular status and diabetic neuropathy at time of diagnosis? 2. Which factors modify the progression of the disease (Nutrition, subclinical inflammation, energy metabolism and physical activity)? 3. Can we identify subgroups at baseline with different progression of the disease? Patients are thoroughly examined at baseline and after 2, 5, and 10 years with annual telephone contacts in between.
Study Type
OBSERVATIONAL
Enrollment
2,000
German Diabetes Center
Düsseldorf, North Rhine-Westphalia, Germany
RECRUITINGChange of insulin sensitivity (M-Value)
measurement of whole body insulin sensitivity with hyperinsulinamic euglicamic clamp
Time frame: 2 and 5 years
Change of insulin secretion
measurement of insulin secretion with glucagon test, mixed-meal test and intravenous glucose tolerance test
Time frame: 2 and 5 years
Incidence of any diabetic complication
The prevalence of diabetic complications
Time frame: 2-10 years
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