Efficacy of Injectable Contraceptive and Oral Contraceptive Administered After Surgical Treatment of Endometriosis With Pain

Prince of Songkla University112 enrolled

Overview

Patients with endometriosis-associated pain have conservative surgery performed to remove all visible lesions. Then, patients are randomized into two groups. In the first group patients have depot medroxyprogesterone acetate injections every 3 months for a total of 6 months.In the second group patients have oral contraceptive combined pills everyday for 6 months. Patients are followed up on recurrence of pain for 1 year after medication.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

112

Conditions

Endometriosis

Interventions

intramuscular depot medroxyprogesterone acetateDRUG

150 mg, Intramuscular, every 3 months

ethinyl estradiol 30 micrograms, gestodene 75 microgramsDRUG

one tablet orally, everyday

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Premenopausal women from 18 to 45 years of age with endometriosis-associated pain for at least 6 months who had conservative surgery performed. Exclusion Criteria: * Medical therapies for endometriosis other than NSAID within previous 6 months * Contraindication to the drugs * Wish to conceive * Request for extirpative surgery * Other pelvic pathology ( adenomyosis, chronic PID, submucous myoma uteri )

Locations (1)

Faculty of Medicine, Prince of Songkla University

Hat Yai, Changwat Songkhla, Thailand

Outcomes

Primary Outcomes

Patients' satisfaction with the treatment

Time frame: 1 year and 6 months

Secondary Outcomes

pain reduction and adverse side effects

Time frame: 1 year and 6 months

Data from ClinicalTrials.gov

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