Studying Gene Expression in Tissue Samples From Young Patients With Acute Myeloid Leukemia

Children's Oncology Group20 enrolled

Overview

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at gene expression in tissue samples from young patients with acute myeloid leukemia.

OBJECTIVES: * Examine mRNA from pediatric patients with acute myeloid leukemia with 11q23 translocations by reverse transcriptase-PCR to quantify expression of EVI1 splice variants. OUTLINE: Cryopreserved mRNA from diagnostic samples is analyzed for gene expression by reverse transcriptase-PCR.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Leukemia

Interventions

RNA analysisGENETIC

gene expression analysisGENETIC

reverse transcriptase-polymerase chain reactionGENETIC

laboratory biomarker analysisOTHER

Eligibility

Sex: ALLMax age: 18 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Diagnosis of pediatric acute myeloid leukemia with 11q23 abnormalities PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Quantification of the expression of EVI1 splice variants

Data from ClinicalTrials.gov

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