Effect of Hyperoxemia on Platelet Function in Healthy Volunteers

University of Zurich50 enrolled

Overview

Prospective, controlled, randomized crossover volunteer study to investigate the effect of hyperoxemia due to inhalation of oxygen (80% inspiratory fraction) via reservoir-face-mask on blood coagulation, especially platelet function, as measured by thrombelastography. According to results of basic animal and in vitro investigations, hyperoxemia may activate platelets by means of reactive oxygen species. This study aims at investigating a possible pro-coagulant effect of hyperoxemia in healthy volunteers. Additional studies on possible mechanisms are integrated. * Trial with medical device

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Healthy Volunteers

Interventions

oxygen inhalationDRUG

Inhalation of 80% oxygen via face mask

Eligibility

Sex: ALLMin age: 25 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: * informed consent; no coagulation disorder or other illnesses; * non-smoker; * women: no pharmacological contraception, negative pregnancy test; * 25-45 years old; no medication; no acute or chronic airway problems; * for 24 hours before study: no extreme physical activity, no polyphenol-containing food (red wine, apples, cabbage, garlic); * for 48 hours: no caffeine-containing drinks, no dark chocolate. Exclusion criteria: * Lack of one of the inclusion criteria; * allergy or incompatibility to substances/materials applied in the study; * very thin veins/arteries.

Locations (1)

Surgical Intensive Care Medicine

Zurich, Switzerland

Outcomes

Primary Outcomes

maximum amplitude in thrombelastography

Time frame: 1 hour

Data from ClinicalTrials.gov

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