Schizophrenia is not a curable but a treatable disease by antipsychotics. Kinds of atypical antipsychotics are widely used since 1990s' in China. Although their efficacy for acute phase are all better than typicals, individulized regimen of them for first-episode schizophrenia and their effectiveness in real naturalistic clinical settings still remain unclear. And those patients also need more comprehensive intervention such as psychosocial programs to improve their function. This protocol is to conduct a study in several sites of China to investigate the effectiveness of comprehensive intervention combining sequenced atypical antipsychotic therapy and intensive psychosocial intervention for first-episode schizophrenic patients. In addition, this protocol also aims at collecting such information as molecular genetics, neurochemical test, neucognitive performance and neuroimaging for outcome analysis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
600
3-6 mg per day
5-20 mg per day
10-30 mg per day
Beijing Anding Hospital
Beijing, Beijing Municipality, China
RECRUITINGBeijing Huilongguan Hospital
Beijing, Beijing Municipality, China
RECRUITINGPeking University Institute of Mental Health
Haidian District, Beijing Municipality, China
RECRUITINGZhongnan University Xiangya Second Hospital
Changsha, Hunan, China
RECRUITINGShanghai Mental Health Center
Shanghai, Shanghai Municipality, China
RECRUITINGSichuan University Huaxi Hospital
Chengdu, Sichuan, China
RECRUITINGthe time the patients remain stable
Time frame: 1 year
Scoring of PANSS and PSP
Time frame: 1 year
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