Impacts of Metabolic Variation on Neuroendocrine Control of Reproduction

Centre Hospitalier Universitaire Vaudois9 enrolled

Overview

This study will evaluate the potential effects of a changing metabolic environment on GnRH hypothalamic neurons, by performing studies of LH pulsatility (basal and during clamp studies) in different groups of male subjects fed isocaloric and hypercaloric diets. The participation of other gastro-intestinal tract hormones to these regulations will be systematically evaluated.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Neuroendocrine Reproductive Status

Interventions

effect of metabolic variations on LH pulsatilityDIETARY_SUPPLEMENT

Isocaloric diet: 1,5 times basal metabolism. Constitution:55% carbohydrates, 15% proteins and 30% fat. Hypercaloric diet: addition of 30% fat and 3 g of fructose/kg of weight to isocaloric diet. PO and IV glucose during clamps: PO administration of 90 mg/kg glucose at 90 minutes intervals during the clamp, and adjustment of the IV perfusion to keep euglycemia.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 25 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * male * age between 18 and 25 years old * no known pathology * normal physical exam * BMI between 20 and 25 kg/m2 Exclusion Criteria: * history of endocrine disease * no known infertility (no conception after 12 months of regular unprotected intercourse) * abnormal results on the initial blood tests (CBC, fasting glucose and insulin, HbA1C, TSH, free T4, LH, FSH, inhibin B and total testosterone)

Locations (1)

CHUVaudois

Lausanne, Switzerland

Outcomes

Primary Outcomes

Luteinizing hormone (LH) pulsatility

Time frame: 2 years

Data from ClinicalTrials.gov

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