Efficacy of Mefenamic Acid and Hyoscine for Pain Relief During Saline Infusion Sonohysterography in Infertile Women

Mahidol University138 enrolled

Overview

The infertility patients who are performed saline infusion sonohysterography (SIS) for studying the pathology inside the uterine cavity has pain. From pilot study the pain score is 6.80. It will have more benefits if we can manage this procedure with less or no pain. Many studies have tried to decrease pain such as types of catheter, intrauterine lidocaine infusion. Some have real effects but no study with oral Mefenamic acid or Hyoscine before the procedure.The drugs are safe and easy to administration and chief.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

138

Conditions

Infertility

Interventions

Mefenamic acid or Hyoscine or placeboDRUG

Mefenamic acid 500 mg. single oral use 30 minutes before SIS Hyoscine 10 mg. single oral use 30 minutes before SIS Placebo single oral use 30 minutes before SIS

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * infertility female * no history of HSG or Hysteroscopy Exclusion Criteria: * vaginal or pelvic infection * abnormal Pap smear * contraindications for Mefenamic acid including upper and lower GI ulcers, bleeding disorder, Asthma or allergies, renal disease, using Warfarin,Aspirin, Lithium, history of Mefenamic acid or Hyoscine allergies

Locations (1)

Siriraj hospital Mahidol university

Bangkok, Bangkok, Thailand

Outcomes

Primary Outcomes

Pain relief by oral Mefenamic acid or Hyoscine and placebo during saline infusion sonohysterography

Time frame: Before, during and after the procedure

Secondary Outcomes

Patients satisfaction during saline infusion sonohysterography

Time frame: After the procedure

Data from ClinicalTrials.gov

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