Study of the Benefit of Exercise and Aminoacid Supplements in Cirrhotic Patients

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau17 enrolled

Overview

This is a pilot study including 20 cirrhotic patients that will be randomized to receive during 3 months leucine vs leucine plus a programme of physical exercise specially designed for cirrhotic patients. The hypothesis is that physical exercise in cirrhotic patients could increase muscle mass (and therefore glutamine synthetase activity leading to a higher blood ammonium clearance) and quality of life. Safety of physical exercise in cirrhotic patients will be strictly assessed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Cirrhosis

Interventions

Leucine supplementsDIETARY_SUPPLEMENT

leucine supplements

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * compensated liver cirrhosis. Exclusion Criteria: * hepatocellular carcinoma, * active alcoholism (less than 1 year), * decompensated cirrhosis, * variceal bleeding less than 3 months, * contraindication for exercise.

Locations (1)

Hospital de la Santa Creu i Sant Pau

Barcelona, Barcelona, Spain

Outcomes

Primary Outcomes

glutamine synthetase activity

Time frame: three months

Secondary Outcomes

quality of life

Time frame: three months

Data from ClinicalTrials.gov

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