Glucose Clamp Study to Prove Hypo- and Hyperglycemic Episodes Using a Non-invasive Glucose Monitoring Device

Inclusion Criteria: Healthy male and female volunteers: * Written informed consent * Aged between 18 and 40 years * Body mass index between 18 and 28 kg/m² * Haemoglobin \> 13 g% Male and female patients with type 1 diabetes: * Known type 1 diabetes, first manifestation 6 months to 15 years before the start of the study * HbA1c \<= 9% * Written informed consent * Aged between 18 and 40 years * Body mass index between 18 and 28 kg/m² * Haemoglobin \> 13 g% Exclusion Criteria: * Uncontrolled arterial hypertension (diastolic blood pressure \>100 mmHg and/or systolic blood pressure \> 180 mmHg) * For women, pregnancy or breast-feeding or, for sexually active women of child-bearing age, the use of contraceptive methods considered to be safe (oral contraceptives, IUD, implanted or injected contraceptives, diaphragms, or surgical sterilisation of the patient or her partner) * Deviations in the lab values (excluding HbA1c), as judged by the investigator to be clinically significant, in particular an increase in transaminases to a level that is two and a half times higher than the upper normal value and a creatinine value that is above the normal range * Severe acute diseases, as judged by the investigator * Severe chronic disease, as judged by the investigator * History of macrovascular illnesses such as pAVK, myocardial infarction * Known microvascular (diabetic) complications (other than diabetic background retinopathy) * Positive serology for hepatitis B, hepatitis C or HIV * Blood donation within 3 months prior to the start of the study and intention of donating blood within 3 months after the end of the study