Effect of Dietary Fat When Eaten With Fructose Versus Glucose

Pennington Biomedical Research Center19 enrolled

Overview

This study is designed to test the effects on liver fat of varying fat intake in the presence of fructose or glucose. We hypothesize that higher dietary fat when eaten with fructose as compared to glucose will increase the amount of hepatic lipid as measured by magnetic resonance spectroscopy.

After 2 screening visits including an exercise test, DEXA and CT scan, qualifiers begin a 7 day diet with 20% fat, 65% carbohydrate (with 20% glucose) and 15 % protein. Participants consume 2 meals per day at PBRC with lunch and weekend meals packed to go. Following a test day, participants are randomized to one of 3 diet assignments and then test again: 1)20% fat, 65% carbohydrate (with 20% glucose beverage), 15% protein 2)40% fat, 45% carbohydrate (with 20% glucose beverage), 15% protein 3)40% fat, 45% carbohydrate (with 20% fructose beverage), 15% protein On Day 7 and again 14 days later participants have labs, an oral Glucose tolerance test, hepatic and intramuscular lipid measures by MRS, vital signs and waist measurement.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Body Weight Changes

Interventions

40% Fat Diet, 20% Fructose BeverageOTHER

40% fat, 45% carbohydrate (with 20% fructose beverage), 15% protein

20% Glucose BeverageOTHER

40% fat, 45% carbohydrate (with 20% glucose beverage), 15% protein

20% Glucose BeverageOTHER

20% fat, 65% carbohydrate (with 20% glucose beverage), 15% protein

Eligibility

Sex: ALLMin age: 28 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI between 25 and 35 kg/m2 inclusive * At least one of the following: 1. Impaired fasting glucose between 100-125 mg/dl inclusive 2. HDL below 40 mg/dl for men or below 50 mg/dl for females 3. Triglycerides between 150 mg/dl and 400 mg/dl inclusive 4. Blood pressure above or equal to 135 / 85 mm Hg * Waist circumference \>94cm (37 inches) for men or \>80cm for women * Mainly Healthy Exclusion Criteria: * Unable or unlikely to eat study foods and only foods provided by PRBC * Taking routine medications except birth control pills * Smoke, Abuse drugs,or Alcohol * Pregnant or breastfeeding, irregular menstrual cycles, Post-menopausal,or PCOS * Diabetes, heart, lung, liver, blood, or Kidney disease

Locations (1)

Pennintgon Biomedical Research Center

Baton Rouge, Louisiana, United States

Outcomes

Primary Outcomes

Evidence to determine whether intake in beverages that provide 20% fructose or a similar beverage made with glucose given with a higher fat diet has an effect on your body weight, blood pressure, fats in your liver or your blood sugar.

Time frame: One Month

Data from ClinicalTrials.gov

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