Efficacy of Topical Rapamycin to Treat Chronic Erosive Oral Lichen

Inclusion Criteria: * Oral Lichen Planus * Oral Erosive Area More Than 1cm² * Lichen Planus Pathologically Proven Exclusion Criteria: * No Previous Treatment by Rapamycin * Non Child Bearing Or Breast Feeding Woman * Patient Who Cannot Be Treated By Rapamycin Or Betamethasone * Chronic Renal Insufficiency (Creatinin Clearance \< 40ml/Mn) * Ongoing Treatment By Topical Calcineurin Inhibitors Or Systemic Steroids Or Retinoids Or Systemic Immunosuppressors Or Thalidomide Or Griseofulvin Or Antimalarials * Cholesterolemia \>7.8 Mmol/L Or Hypertriglyceridemia \>3.95mmol/L Non Responsive To Medical Treatments * Leucopenia (\<3000/Mm3) * Thrombopenia (\<100 000/Mm3) * Hypertransaminasemia (\>3n) * Hypersensitivity To Macrolides