Intravenous Lidocaine for Laparoscopic Cholecystectomy

McGill University Health Centre/Research Institute of the McGill University Health Centre80 enrolled

Overview

Intravenous lidocaine has been shown to have analgesic, antinflammatory, antihyperalgesic, antithrombotics and neuroprotective properties. In a previous study conducted in patients undergoing laparoscopic cholecystectomy under general anesthesia with desflurane and fentanyl, intraoperative i.v. infusion of lidocaine spared opioids consumption in the recovery room by 30%. The purpose of this study was to determine if an i.v. infusion of lidocaine without intraoperative opioids would reduce the amount of fentanyl to the same extent and opioids-related side effects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Postoperative Pain Opioid Consumption

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing laparoscopic cholecystectomy Exclusion Criteria: * age \<18 yr or \> 85 yr, * ASA physical status 3 and greater, history of hepatic failure (Child \& Pug A-C), * renal failure (creatinine outside the normal range) or cardiac failure (NYHA I-IV), * Adams-Stoke syndrome, * severe degrees of sinoatrial, atrioventricular or intraventricular block, * organ transplant, * diabetes mellitus type 1 and 2, * morbid obesity (BMI \> 40), * chronic use of opioids and beta-blockers, * known seizures, * severe mental impairment, * allergy to local anesthetics and to all the medications used in the study, or * inability to understand pain assessment.

Outcomes

Primary Outcomes

Fentanyl consumption (measured as fentanyl equivalents -mcg)

Time frame: postoperative day 0 (day of surgery before beeing discharged home) and 24 hr after the end of surgery

Secondary Outcomes

Pain, Static and Dynamic

Time frame: On postoperative day 0 (day of surgey before beeing discharged home) and 24 hrs after the end of surgery

Opioids side-effects

Time frame: On postoperative day 0 (before beeing discharged home) and at 24 hrs after the end of surgery