This project may help to answer several fundamental questions related to public health regarding vaccination against influenza viruses and regarding the influenza A(H1N1)v pandemy: What is the immunologic efficacy in terms of antibodies response of the vaccination against the seasonal (2009-2010) influenza virus and against the A(H1N1)v virus in the clinical staff? Moreover, it may help to answer questions related to the use of a vaccine against influenza virus variants emerging in the French population: 1. Before the vaccination: * What is the status of the residual anti-H1N1 seasonal viruses immunity and of the anti-A(H1N1)v immunity in the population stratified by age and taking into account the multiplicity of the prior seasonal vaccinations? * What is the level of the cellular and humoral cross-reactivity between the different H1N1 strains? 2. After the vaccination: * What is the intensity of the anti-vaccine immune response as a function of the age of the population ad of the prior seasonal vaccinations? * What is the level of the cellular and humoral cross-reactivity after vaccination as a function of the age of the population and of the multiplicity of the prior seasonal vaccinations?
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
147
Inclusion of hospital personnel in the context of the anti-H1N1v prophylaxy plan.
Hopital Pitie Salpetriere
Paris, Île-de-France Region, France
Centre d'Investigations Cliniques (CIC), Hopital Cochin
Paris, Île-de-France Region, France
Evaluation of the intensity of the humoral and cellular immune responses of the anti-A(H1N1)v vaccine in a medical care population as a function of the age and of the prior seasonal anti-influenza vaccinations.
Time frame: 5 months
Investigate the quality of the humoral and cellular immune responses induced by the seasonal anti-influenza vaccine as a function of the age and of the prior seasonal vaccinations.
Time frame: 5 months
Determine the cross-reactivity of the humoral and cellular immune responses as a function of the age and of the prior seasonal vaccinations
Time frame: 5 months
Assess the tolerance to the seasonal and pandemic vaccines
Time frame: 5 months
Assess the occurence of flu episodes and their severity during the 2009-2010 season as a function of the age of the population. Then, the correlation between the flu episodes and and the immunologic results is to be evaluated.
Time frame: 5 months
Evaluate the perception of the anti-influenza vaccination in a medical care population in the current H1N1v pandemy context.
Time frame: 5 months
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