Intrauterine Human Chorionic Gonadotrophins (hCG) and Endometrial Treg Cells

The Egyptian IVF-ET Center20 enrolled

Overview

Intrauterine injection of hCG around the time of implantation may increase endometrial Treg cells and improve implantation. It has been demonstrated that regulatory T cells expand during pregnancy. hCG was found to be secreted by the embryo immediately after fertilization and has chemoattractant properties to Treg cells.

Aim of the work: To study the effect of intrauterine injection of human chorionic gonadotrophin on the endometrial T regulatory cells (Treg cells)and the electromicroscopic endometrial characteristics. Background: It has been demonstrated that regulatory T cells expand during pregnancy and are present at the feto-maternal interface at very early stages in pregnancy. Rational: Intrauterine injection of hCG around the time of implantation may increase endometrial Treg cells and improve implantation. Methods: Intrauterine injection of 100 IU hCG will be done followed by endometrial biopsy to check for Treg cells and pinopodes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

DOUBLE

Enrollment

Conditions

Infertility

Interventions

human chorionic gonadotrophinDRUG

intrauterine injection of 100 IU hCG followed by endometrial biopsy .

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 38 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male factor infertility * Ovulatory factor infertility * Unexplained infertility * Female age less than 39 Exclusion Criteria: * Azoospermia * Tubal factor infertility * Pelvic endometriosis

Locations (1)

Cairo University

Cairo, Egypt

Outcomes

Primary Outcomes

the presence of Treg cells and pinopodes in the endometrium

Time frame: 4 weeks

Secondary Outcomes

pregnancy rate

Time frame: 4 weeks

Data from ClinicalTrials.gov

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