PRM-151 in the Prevention of Scarring Following Trabeculectomy

Inclusion Criteria: * Men or women of nonchildbearing potential (WONCBP) aged 18 years and older at screening. * Diagnosis of chronic angle-closure glaucoma or open-angle glaucoma, phakic or pseudophakic, with visual field or optic disc changes characteristic of glaucoma. For pseudophakic glaucoma patients, the cataract surgery performed was with phacoemulsification and through a corneal incision. * Suitable candidate for trabeculectomy in the study eye which the physician deems as medically necessary. Exclusion Criteria: * Diagnosis of glaucoma other than chronic angle-closure glaucoma or open-angle glaucoma (ie., uveitic, traumatic or neovascular glaucoma). * Any previous ocular surgeries in the study eye involving the upper conjunctiva and sclera. * History of laser surgeries in the study eye within 90 days before day 1. * Presence or history of any disease that could affect wound healing. * Any asymmetric abnormality of the anterior segment which requires additional intervention (surgery or medication). * Any abnormality other than glaucoma in the study eye that could affect tonometry. * Presence or history of uveitis within 10 years or any other ocular infection or inflammation within 14 days before day 1. * Clear corneal phacoemulsification performed within 90 days before day 1.