Pangenomic Study During Alcoholic Cirrhosis

Nantes University Hospital1,325 enrolled

Overview

Hepatocellular carcinoma (HCC) is a frequent complication of cirrhosis. Occurrence of HCC could be linked with multiple functional region of genome. The determining of a genomic mapping of " single nucleotide polymorphisms " (SNPs) permit to perform some genetic link studies with pathologies without clear hereditary disposition. In this study, the investigators will identify predictives genetic polymorphism of HCC.

Study Type

OBSERVATIONAL

Enrollment

1,325

Conditions

Alcoholic Cirrhosis

Interventions

DNA extractionGENETIC

DNA extraction of blood sample for DNAship analysis

Eligibility

Sex: ALLMin age: 35 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 35 to 70 years old * Compensated cirrhosis or not * Caucasian origin of the parents * Patient with cirrhosis (histological proof or obvious) Exclusion Criteria: * HIV, HBV, HCV positive * Known Homozygotia (C282Y+/+) * Important hepatocytary iron overload for patient with resection * HCC non histologically prooved

Locations (4)

Nantes UH

Nantes, France

Jean Verdier UH

Paris, France

Paul Brousse UH

Paris, France

Rennes UH

Rennes, France

Outcomes

Primary Outcomes

Existence of HCC and Pangenomic analysis of DNA polymorphism

Existence of HCC and determination of which genetic polymorphism are predisposing to HCC or preventing for HCC

Secondary Outcomes

cirrhosis severity (compensated or not)

Analysis of the genetic polymorphism involved in the severity of cirrhosis

Data from ClinicalTrials.gov

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