The propose of the study is to investigate the efficacy of Mindfulness-based Cognitive Therapy (MBCT, Segal, Williams, \& Teasdale, 2002) for patients suffering from Chronic Major Depression. The efficacy of MBCT will be compared with the Cognitive Behavioral Analysis System of Psychotherapy (McCullough, 2003), a treatment approach, which has proven it's efficacy yet, and with a treatment-as-usual condition (standard psychiatric outpatient care).
Cognitive Behavioral Analysis System of Psychotherapy (CBASP) is a treatment approach specifically developed for the treatment of chronic depression. CBASP aims to change dysfunctional interpersonal patterns. Mindfulness-based Cognitive Therapy (MBCT) has recently been proposed as a further treatment option for chronic depression. MBCT trains patients to step out of negative ruminative states of mind. There are no direct comparisons of the psychological treatment options for chronic depression.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
106
Mindfulness-based Cognitive Therapy is based on an integration of aspects of cognitive behavioral therapy for depression (Beck et al., 1979) with components of the Mindfulness-based Stress Reduction program developed by Kabat-Zinn and colleagues (Kabat-Zinn, 1990). After an initial orientation session, the MBCT program is delivered by an instructor in eight weekly 2.5 hr group sessions
The Cognitive Behavioral Analysis System of Psychotherapy integrates behavioral, cognitive, and interpersonal strategies. After two initial orientation sessions, the MBCT program is delivered weekly by an instructor in eight 2.5 hr group sessions.
University of Hildesheim
Hildesheim, Germany
Hamilton Rating Scale for Depression
Time frame: Change from Baseline in HAM-D at 8 weeks
Beck Depression Inventory II
Time frame: Change from Baseline in BDI-II at 8 weeks
Social Adaption Self-evaluation Scale
Time frame: Change from Baseline in SASS at 8 weeks
Short Form (36) Health Survey
Time frame: Change from Baseline in SF-36 at 8 weeks
Global Assessment of Functioning Scale
Time frame: Change from Baseline in HAM-D at 8 weeks
Response Styles Questionnaire
Time frame: Change from Baseline in RSQ at 8 weeks
Beck Depression Inventory II
Time frame: Change from Baseline in BDI-II at 6 months
Social Adaption Self-evaluation Scale
Time frame: Change from Baseline in SASS at 6 months
Short Form (36) Health Survey
Time frame: Change from Baseline in SF-36 at 6 months
Global Assessment of Functioning Scale
Time frame: Change from Baseline in GAF at 6 months
Response Styles Questionnaire
Time frame: Change from Baseline in RSQ at 6 months
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Antidepressant medication and medical care. Standard psychiatric outpatient care: All patients were requested to get treated individually either by a psychiatrist or by a licensed psychotherapist (not member of the study team). If patients were already in psychiatric/psychotherapeutic individual treatment at study intake they continued their treatment with this psychiatrist/psychotherapist