Comparison of Two Doses of Intranasal Dexmedetomidine as Premedication in Children

The University of Hong Kong104 enrolled

Overview

Intranasal dexmedetomidine has shown to be an effective sedative when used prior to anaesthetic induction as premedication. 1mcg/kg intranasal dexmedetomidine was used in previous study and it produced satisfactory sedation in more than 50% of the children at the time of anaesthetic induction with no adverse effect. In this study we aim to compare 1mcg/kg with 2mcg/kg intranasal dexmedetomidine in children. We expect more children would attain satisfactory sedation prior to anaesthetic induction when higher dose is used.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

104

Conditions

Patient Between 1-8 Years Old Undergoing Elective Surgery at Queen Mary Hospital

Interventions

DexmedetomidineDRUG

Intranasal dexmedetomidine is given as premedication prior to induction of anesthesia

Eligibility

Sex: ALLMin age: 1 YearMax age: 8 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 1-12 years old * American Society of Anesthesiologists (ASA) 1-2 * Elective surgery * Children with autism or pervasive personality disorder Exclusion Criteria: * American Society of Anaesthesiologists (ASA) 3-5 * Allergy or hypersensitive reaction to dexmedetomidine * Known cardiac arrhythmia or congenital heart disease * Mentally disabled

Locations (1)

QUeen Mary Hospital

Hong Kong, Hong Kong

Outcomes

Primary Outcomes

proportion of children attained satisfactory sedation

Time frame: one hour

Secondary Outcomes

time to onset of sedation

Time frame: one hour

Data from ClinicalTrials.gov

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