Effects of Endoscopic Sinus Surgery for Chronic Sinusitis on Asthma Control

Inclusion Criteria: * Inclusion criteria: General 1. 18 years of age or older 2. Women need one of the following: negative pregnancy test or suitable birth control or post-menopausal status 3. Informed consent and ability to comply with study procedures 4. Patients must meet inclusion criteria for both asthma and sinus disease. Inclusion criteria: Asthma In order to qualify for the 6 week run-in, patients must have poorly controlled asthma as defined by the following criteria: 1. Diagnosis of asthma confirmed either by demonstrating a positive methacholine challenge test (defined as a decrease in FEV1 by at least 20%, following administration of 8mg or less of inhaled methacholine) or a positive bronchodilator response (defined as a change from base line of \>12% and at least 200ml in either FEV1 or FVC, following administration of a short-acting, inhaled bronchodilator). 2. Either: * Asthma Control Questionnaire score \> 1.5 or * Use of inhaled rescue ß-agonist \>/= 16 puffs per week (excluding use as a pre-medication for exercise; 1 nebulizer treatment = 2 puffs of inhaler) at any time during the past month or * \>1 hospitalization or unscheduled MD visit in the past 6 months for asthma symptoms or * \>1 course of oral steroid use in past 6 months or * \> 2 weeks of systemic steroids in last 6 months. Exclusion Criteria: 1. Current smokers or those with at least a 10 pack-year smoking history 2. Presence of any concurrent diseases that, in the investigator's opinion, would interfere with participation in the study or that might put the participant at risk