The Effect of Tekturna on Endothelial Function and Endothelial Progenitor Cells in Patients With Early Atherosclerosis

Inclusion Criteria: 1. Age \> 18 years old 2. More than two of the following cardiovascular risk factors (determined by prescreen phone call): family history of cardiovascular disease, physical inactivity/sedentary lifestyle, obesity or overweight, family history of diabetes mellitus or hypertension, total cholesterol \> 200 mg/dL, LDL \> 130 mg/dL, HDL \< 50 mg/dL, smoking, stress, or Triglycerides \> 150 mg/dL 3. Demonstrated endothelial dysfunction (reactive hyperemia - EndoPAT score \< 2.0) at time of screening Exclusion Criteria: 1. Serum potassium \> 5.0 mmol/L documented at any time prior to the study 2. History of any cardiovascular event (stroke, transient ischemic attack (TIA), myocardial infarction (MI), unstable angina, coronary artery bypass grafting (CABG), percutaneous coronary intervention, hospitalization due to heart failure) during the 3 months prior to the study 3. Hypertension or hypotension (at Randomization): any patient with Mean Seated Systolic Blood Pressure (msSBP) ≥ 170 mmHg, msSBP \< 100 mmHg or Mean Seated Diastolic Blood Pressure (msDBP) ≥ 110 mmHg 4. Congestive heart failure New York Heart Association (NYHA) class III and IV 5. Concomitant treatment with two (2) or more renin-angiotensin-aldosterone system blocking agents, e.g. Angiotensin Converting Enzyme Inhibitor (ACEI), Angiotensin II receptor blockers (ARB) or aldosterone-antagonist 6. Unstable serum creatinine 7. Second (II) or third (III) degree heart block without a pacemaker 8. Concurrent potentially life threatening arrhythmia or other uncontrolled arrhythmia 9. Clinically significant valvular heart disease 10. Known renal artery stenosis 11. Any surgical or medical condition which might significantly alter the absorption, distribution, metabolism, or excretion of the study drugs including, but not limited to, any of the following: * History of major gastrointestinal tract surgery such as gastrectomy, gastroenterostomy, or bowel resection * Any history of pancreatic injury, pancreatitis or evidence of impaired pancreatic function/injury as indicated by abnormal lipase or amylase * Evidence of hepatic disease as determined by a history of hepatic encephalopathy, a history of cirrhosis, esophageal varices, or a history of portocaval shunt 12. History of malignancy other than basal cell skin cancer within the past five years 13. Any concurrent life threatening condition with a life expectancy less than 2 years 14. History or evidence of drug or alcohol abuse within the last 12 months 15. Any surgical or medical condition, which in the opinion of the investigator, may place the patient at higher risk from his/her participation in the study, or is likely to prevent the patient from complying with the requirements of the study or completing the study 16. History of hypersensitivity to any of the study drugs or to medications belonging to the same therapeutic class as the study drugs as well as known or suspected contraindications to the study drugs 17. History of noncompliance to medical regimens or unwillingness to comply with the study protocol 18. Use of other investigational drugs at the time of enrollment, or within 30 days or 5 half-lives of enrollment, whichever is longer 19. Any condition that in the opinion of the investigator would jeopardize the evaluation of efficacy or safety 20. Persons directly involved in the execution of this protocol 21. Pregnant or nursing (lactating) women 22. Women of Child-Bearing Potential (WOCBP) unless postmenopausal for at least one year, surgically sterile or using effective methods of contraception as defined by local Health Authorities