The Effect of Tranexamic Acid on Postoperative Blood Loss and Coagulation in Patients With Preoperative Anemia Undergoing Off-Pump Coronary Artery Bypass Graft; Double Blind Randomized Control Study

Yonsei University90 enrolled

Overview

The Effect of Tranexamic Acid on Postoperative Blood loss and Coagulation in Patients with Preoperative Anemia Undergoing Off-Pump Coronary Artery Bypass Graft; double blind randomized control study.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Coronary Artery Occlusive Disease

Interventions

Tranexamic AcidDRUG

1.0g loading dose before skin incision and continuous infusion 200 mg/h during surgery

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Fifty patients undergoing OPCAB with preoperative hematocrit levels lower than 35% Exclusion Criteria: Patient who has * Open heart surgery history before * Thrombosis history * Myocardial infarction (MI) within 7days recently * Liver or Kidney disease * been scheduled emergency surgery

Locations (1)

Yonsei Univ.

Seoul, South Korea

Outcomes

Primary Outcomes

Tranexamic acid significantly reduce the amount and incidence of homologous transfusion in anemic patients undergoing off-pump coronary artery bypass (OPCAB)

Time frame: Check the amount 3 times before sugery and 24 hours after surgery

Data from ClinicalTrials.gov

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