Prognostic Value of Progesterone for In Vitro Fertilization (IVF) Outcome

Aristotle University Of Thessaloniki130 enrolled

Overview

This observational study attempts to investigate the potential role of serum progesterone levels on the day of hCG administration (thus, the end of the follicular phase) on the probability of pregnancy, in patients undergoing IVF with the use of GnRH antagonists and recombinant gonadotrophins. There has been evidence, that increased serum levels of progesterone are associated with a decreased probability of pregnancy after IVF. This study will attempt to explore the role of progesterone on the outcome of IVF, by closely monitoring its levels during the late follicular phase.

Study Type

OBSERVATIONAL

Enrollment

130

Conditions

Subfertility

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 39 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \< 40 years * Basal FSH \< 12 IU/L * Basal P \< 1.6 ng/mL Exclusion Criteria: * Presence of cystic formations at the ovaries during the basal ultrasound scan (prior the initiation of stimulation) * Women with polycystic ovaries syndrome (PCOS) * Women with Stage III-IV Endometriosis * Women with a pathological condition of the adrenal glands

Locations (1)

Unit for Human Reproduction, 1st Dept. of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki

Thessaloniki, Greece

Outcomes

Primary Outcomes

Clinical pregnancy, defined as ultrasound evidence of fetal heart activity at 6-8 weeks of gestation

Time frame: At 6-8 weeks of gestation

Secondary Outcomes

Pregnancy (defined as a b-hCG> 25 IU/L)

Time frame: 12 days after embryo transfer

Data from ClinicalTrials.gov

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