Safety and Pharmacokinetic Study With Multiple Ascending Doses of ORM-12741

Inclusion Criteria: * Good general health ascertained by detailed medical history and physical examinations. * Males between 18 and 45 years (inclusive). * Body mass index (BMI) between 18-30 kg/m2 inclusive (BMI = weight/height2). * Weight 55-100 kg (inclusive). Exclusion Criteria: * Evidence of clinically significant cardiovascular, renal, hepatic, haematological, gastro-intestinal, pulmonary, metabolic-endocrine, neurological, urogenital or psychiatric disease as judged by the investigator. * Any condition requiring regular concomitant medication including herbal products or likely to need any concomitant medication during the study. * Susceptibility to severe allergic reactions. * Regular consumption of more than 14 units of alcohol per week (1 unit = 4 cl spirits, about 13 g of alcohol). * Current use of nicotine-containing products more than 5 cigarettes or equivalent/day. * Inability to refrain from using nicotine-containing products during the stay at the study centre. * Inability to refrain from consuming caffeine-containing beverages during the stay at the study centre e.g. propensity in getting headache when refraining from caffeine-containing beverages. * Blood donation or loss of significant amount of blood within 3 months prior to the screening visit. * Abnormal finding in ECG, vital signs, laboratory tests or physical examination. * Intake of an investigational compound within 3 months prior to the start of this study or earlier participation in a clinical study with ORM-12741