Validation of Pharmacogenetics Plus Drug Combination Guided Initial Tacrolimus Dosage in Renal Transplant Recipients

Inclusion Criteria: 1. Adult (both males and females, 18-65 years) recipients underwent single primary renal transplantation in the First Affiliated Hospital of Sun Yat-sen University 2. Wish to participate in the study 3. Informed consent for the trial Exclusion Criteria: 1. Patients with abnormal hepatic function, serious infection, malignant tumour, and diabetes mellitus 2. Patients with ABO-incompatible renal transplantation 3. Panel reactive antibody (PRA) levels greater than 30% before transplantation 4. Underwent combined organ transplantations 5. Except for SchE, other medication known to affect tacrolimus blood levels, such as diltiazem, verapamil, ketoconazole, itraconazole, erythromycin or clarithromycin was used 6. Allergic history to study medicines 7. During pregnancy or plan to get pregnant during the study period