Hypothesis: Vitamin D supplementation lower renin-angiotensin system activity in obesity. Specific Aim: To investigate whether Vitamin D supplementation in obesity improves the vascular sensitivity to angiotensin II.
Vitamin D deficiency and obesity are international epidemics that have both been associated with increased activity of the renin-angiotensin system (RAS). Because increased RAS activity is associated with cardiovascular disease, interventions to lower RAS will have favorable public health impacts. This study aims to evaluate whether the supplementation of Vitamin D in obese subjects will lower local tissue RAS activity. RAS activity will be evaluated by cross-sectional measurement of RAS components and by quantifying the vascular response to an infusion of angiotensin II. Subjects will be studied while Vitamin D deficient, and will return for repeat study following Vitamin D supplementation, for comparison.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
26
cholecalciferol 15,000 IU daily for 30 days
Brigham and Women's Hospital
Boston, Massachusetts, United States
The Change in the Mean Arterial Blood Pressure in Response to an Infusion of Angiotensin II
Time frame: baseline and 1 month following vitamin D3 therapy
The Change in Renal Blood Flow in Response to an Infusion of Angiotensin II
Time frame: baseline and 1 month following vitamin D3 therapy
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