Analysis of Proinflammatory Factors in the Synovial Fluid In Patients With Rotator Cuff Disease

Tel-Aviv Sourasky Medical Center40 enrolled

Overview

Role of proinflammatory factors in Patients with Rotator Cuff Disease Objective: To measure the levels of various cytokines and metalloproteases in patients with rotator cuff disease, and control group and to determine the correlations among them.

We hypothesize that cytokines and MMP's level will be significantly higher in patients with RC pathology than in control group and will be related to the time frame since injury (i.e. - higher levels as close to the injury). In addition we will examine possible relation of those levels to the pain curve by using Visual Analogue Scale.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Rotator Cuff Disease

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Ability to understand and accept the trial procedures and to sign an informed consent form in accordance with national legislation. 2. Patients between age 18-65 scheduled for a surgery in a Shoulder unit 3. Patients suffering from Rotator Cuff Disease 4. Patients suffering from any noninflammatory shoulder condition which requires surgical intervention Exclusion Criteria: 1. Revision rotator cuff repair 2. Recurrent shoulder surgery 3. Psychiatric illness 4. Inflammatory condition. 5. Current use of anti-inflammatory drugs. 6. Previous or current shoulder infection.

Outcomes

Primary Outcomes

cytokines and MMP's levels in patients with RC pathology and in control group

Time frame: 12 month

Secondary Outcomes

Levels of pain curve by using Visual Analogue Scale

Time frame: 12 month

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.