Efficacy and Akathisia Incidence of Slow Infusion Metoclopramide

Inclusion Criteria: * Patients 18 through 65 years of age and 50-90 kg of weight who presented to the ED with primary or secondary complaints of moderate to severe nausea who not use of commonly accepted antiemetic within the previous 24 hours were eligible for this study. * Their peripheral oxygen saturation level was 90% or over while respirating room air and free of any respiratory problems. Exclusion Criteria: * Patients with mild symptoms of nausea * Altered mental status * Abnormal vital signs * Any known allergy to the metoclopramide * Previously enrolled in the study * Known renal failure or insufficiency * GIS hemorrhage, ileus and/or perforation * Women who were pregnant and lactating * Those with a history of epilepsy * Admitted to the ED due to acute psychiatric symptoms * Restless legs syndrome * Parkinson * Organic brain disease * Phaeochromocytoma * Patient with alcohol * Anticholinergic, sedative, hypnotic, trankilizan, digoxin, cimetidine, tetracycline and levo-dopa use * Presence of severe agitation akathisia can not be evaluated and uncooperative individuals.